Quality is the essence of any product or service. We gauge the worth of any good or service by the quality of it. Quality is essence is impacted by different elements for different products and services too. For food and biotechnology industries, quality is one of the most vital areas of care. Controlling the quality of its ingredients gives a manufacturer complete control over the quality of the end product. An important aspect of materials used in biotechnology and pharmaceutical manufacturing is the purity of it.
Purity plays an important role in the pharmaceutical manufacturing industry. The process of generating and maintaining good quality products can be a tedious task. Plant managers employ several processes and use various applications to keep up to date with the quality and purity requirements of the regulatory agencies. In this way, the maintenance of systems becomes an important task for plant managers. They need to proactively take care of the production system and equipment before am issue arises. At the same time, they cannot hinder production in any way. Here they use, steam in place systems. Steam in place or SIP system is used for sterilizing the equipment and cleaning them internally with steam to achieve the appropriate purity levels. SIP systems are integrated into sterile blending vessel, storage and distribution systems as well to clean them without the need for disassembly. For example, in Pharmaceutical manufacturing industries, to prevent inter-batch contamination, a cleaning procedure with SIP systems as the last step ensures sanitized internals of the sterile blending vessel and other systems for the next batch. In this way, SIP systems can be incorporated in processing vessels and piping, filtered water supplies, process liquid filters, valves, pumps and all kinds of process instrumentation in a many industries.
While performing a SIP on process equipment, there are some things you need to take care of for effective sanitization.
1. Plan steam flow and process flow in the same direction
Having the steam flow in the same direction of the process helps you take advantage of the existing process piping and support processes. Planning the piping system can avoid dead-ends and non-drainable low points that can create condensate pools or air pockets which are detrimental to the quality of pure steam running through the system.
2. Ensure uniform steam quality
The effectiveness of a SIP system largely depends on the stem that is used for sterilization. The steam running through the system needs to be of the highest quality. It should be at the right temperature to effect sterilization. Various regulatory agencies have set quality standards for SIP systems and the steam within it. Both must meet the requirements for clean steam.
3. The CIP – SIP combination
A SIP system needs to be run in combination with a CIP or clean-in-place system that uses chemicals to clean the systems internally. CIP needs to be run first and then a SIP. The SIP steam cleaning sterilizes the entire system while also cleaning ay chemicals leftover from CIP cleaning.
Propack technologies is a leading manufacturing company in India. We design state-of-the-art process equipment and plans for your pharmaceutical operations. Our sterile blending vessel, piping systems, storage, and distribution systems are made from high-quality materials and in compliance with quality standards of regulatory agencies. We are at the forefront of innovating new and improved systems for helping our producing partners manufacture better products.